chloroquine coronavirus

Update:  President Trump Announces FDA approves Chloroquine for treatment of Covid-19.

At 3:04PM March 19, 2020, President Trump announced during his call to Governors that Chlorquine and HydroxyChloroquine are approved for treatment.  Good News if this is implemented across all 50 states.

Gregory Rigano- Stanford University Medical School Advisor Speaks on Tucker Carlson

Gregory Rigano- https://twitter.com/RiganoESQ

Fast forward to 43:12 to hear about a peer review study of 40 patients in France by Didier Raoult MD, PhD.  This clinical trial suggested according to Mr. Rigano that the results of Hydroxychloroquine to treat Coronavirus results provided 100% cure.   While this is early and as you can read below, that Chloroquine has been studied and reported last month in China.  The question remains how the efficacy is on a larger test group.

 

What is this initiative?

“We’re an independent group of scientists and physicians working on an open-data clinical trial for prevention of COVID-19, through the use of hydroxychloroquine in combination with other therapeutic agents.

Unlike a typical commercial drug trial, our objective is to share trial data with the public* and health-care professionals as close to real-time as possible (with a reasonable level of data quality assurance).”

Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment ofCOVID‐19: results of an open‐label non‐randomized clinical trial. International Journal ofAntimicrobial Agents – In Press 17 March 2020 – DOI 10.1016/j.ijantimicag.2020.105949

Didier Raoult

Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.

Didier.raoult@gmail.com

Given the rapidly spreading coronavirus pandemic, we’re looking for every possible means to fast-track the effort.”- CovidTrial.io

For more details:  See https://www.covidtrial.io/

https://www.mediterranee-infection.com/wp-content/uploads/2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf

Does Italy Have More COVID19 Deaths Than South Korea Because They’re Not Prescribing Chloroquine?

As of March 15¹, Korea has 8162 infections, but only 75 deaths, a death rate of 0.91%. By comparison, Italy has 24,747 infections and 1809 deaths, a death rate of 7.3%.

I have been living in Hubei Province, very close to Wuhan, so I am very familiar with this situation.

The WHO is distributing inadequate Coronavirus treatment guidelines for worldwide use, which Italy is following.

The Italian government health website (archive) updated on March 4 states:

There is no specific treatment for the disease caused by a new coronavirus.. Treatment is based on the patient’s symptoms and supportive care can be very effective. Specific therapies and vaccines are being studied.

However, both Korea and China have been treating infections with drugs known as Chloroquine (long known to treat malaria) or Kaletra (used for the treatment of HIV/AIDS, contains lopinavir/ritonavir ).

The Korean guidelines were published on February 12, 2020. The Chinese have repeatedly told us they are using both these drugs. At this point, Chinese sources have made it clear they believe this situation is under control. Informally 5 of my Chinese friends have confirmed this is true, only that non Chinese are still restricted from moving around in China.” Adrian Bye, Medium.com March 16, 2020

https://medium.com/@adrianbye/is-the-high-coronavirus-death-rate-caused-by-wrong-official-treatment-guidelines-f4ef0a2903f3

Chloroquine In Use Since 1934. Safe, approved for years.

“Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor α and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.” Published: November, 2003

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(03)00806-5/fulltext

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

“The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.” February 19, 2020

https://www.ncbi.nlm.nih.gov/pubmed/32074550